Published Research & News
Be sure to scroll down this page to see the Research on Black Raspberries.
BerriHealth Press Releases *
June 29, 2014 BerriHealth launches the first in a line of new fiber products, blending berry powders from their Oregon farm with organic psyllium to make great-tasting and health fiber without artificial colors, sweeteners, and sugars.
BerriHealth Supports Cancer Research
February 21, 2014 -- BerriHealth continues to support research for the neuroendocrine tumor and carcinoid cancer community.
Berri Products LLC Now Member of Northwest Food Processors Association
January 31, 2014 -- Oregon berry product innovator, Berri Products, announces membership to the Northwest Food Processors Association.
BerriHealth.com Launches Innovative New Berry Powder Blend Containing Full Servings of Premium Berries
September 18, 2013 -- BerriProducts LLC has launched a new product, BerriSpectrum™ AnthoBlend™, that contains a full serving of whole organic California strawberries and Washington blueberries, along with a full serving of their own specially-cultivated Oregon black raspberries.
Black Raspberry Inhibits Angiogenesis in Human Carcinoid Cancer Tumor Assays
June 25, 2013 -- BerriProducts LLC, an Oregon-based supplier of premium quality black raspberry products shares news from the recently-attended Berry Health Benefits Symposium on angiogenesis inhibition with an in vitro test on human carcinoid cancer cells
Hepatitis A Outbreak in Costco Organic Berry Blend Linked to Pomegranate Imported From Turkey
June 06, 2013 -- BerriProducts LLC assures customers that their products are not affected by the recent hepatitis A outbreak due to their high level of quality control and use of locally-sourced berries.
Black Raspberry Capsule Craze Not Supported By Research
April 24, 2013 -- BerriProducts LLC, an Oregon-based supplier of premium quality black raspberry products, sets the record straight on black raspberry capsules.
Black Raspberries Reduce DNA Damage in Oral Cancer Survivors
April 11, 2013 -- BerriProducts LLC shares a human clinical trial that suggests consumption of phytonutrient-rich black raspberries by oral cancer survivors reduces biochemical markers of DNA damage, is safe, and is well tolerated by oral cancer survivors.
Black Raspberries May Inhibit Prostate Cancer
April 10, 2013 -- BerriProducts LLC, an Oregon-based company that supplies black raspberry products for clinical trials, shares new research that suggests black raspberries may be beneficial in reducing prostate cancer tumor incidence in rats. The black raspberry powder used in this study was provided by BerriProducts LLC.
Black Raspberries Slow Colon Cancer Growth and Reduce Inflammation in Colorectal Cancer Patients
April 09, 2013 -- BerriProducts LLC shares new research in human colorectal cancer patients that bolsters the growing body of evidence supporting the cancer-preventive effects of black raspberries and suggests that eating black raspberries beneficially alters fat metabolism to reduce cancer risk.
Three Myths About Black Raspberry Capsules Demystified
June 19, 2012 -- BerriHealth shows that only 1.5 black raspberries are included in one 300mg freeze-dried capsule not the two cups, or 160 berries claimed. The USDA considers 40 black raspberries to be one nutritional serving. This is the equivalent of quantity 27 - 300mg capsules, therefore rendering the "two capsules per day" recommended dose nutritionally ineffective.
Independent Research Publications from PubMed *
Listed below are links to US National Library of Medicine PubMed references of independent research publications done with black raspberries. They are sorted under general categories with the link titles giving a description of the research focus. Please click on the link to view the abstract or article.
General Scientific Black Raspberry Publications:
Newly Added: Protective effect of black raspberry seed containing anthocyanins against oxidative damage to DNA, protein, and lipid
- Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes
- The antimicrobial activity of fruits from some cultivar varieties of Rubus idaeus and Rubus occidentalis.
- Mistaken identity: clarification of Rubus coreanus Miquel (Bokbunja).
- Characterization of Black Raspberry Functional Food Products for Cancer Prevention Human Clinical Trials.
- Berries and Human Health: Research Highlights from the Fifth Biennial Berry Health Benefits Symposium.
- Foodstuffs for preventing cancer: the preclinical and clinical development of berries.
- Anthocyanins and their role in cancer prevention.
- Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries.
- Bioactive food components and cancer risk reduction.
- Cancer prevention with freeze-dried berries and berry components.
- Molecular mechanisms involved in chemoprevention of black raspberry extracts: from transcription factors to their target genes.
- Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days.
- Black raspberry extract and fractions contain angiogenesis inhibitors.
- Inhibition of cellular transformation by berry extracts.
- Perspectives in cancer chemoprevention.
- Cancer chemoprevention: principles and prospects.
Black raspberry and the lower GI tract:
- New in 2015: Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells.
- New in 2015: Beneficial Regulation of Metabolic Profiles by Black Raspberries in Human Colorectal Cancer Patients.
- New in 2015: Black raspberries suppress colonic adenoma development in ApcMin/+ mice: relation to metabolite profiles.
- Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells.
- Plasma cytokines as potential response indicators to dietary freeze-dried black raspberries in colorectal cancer patients.
- Effect of black raspberry ( Rubus occidentalis L.) extract variation conditioned by cultivar, production site, and fruit maturity stage on colon cancer cell proliferation.
- Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study.
- Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis.
- Black raspberries inhibit intestinal tumorigenesis in apc1638+/- and Muc2-/- mouse models of colorectal cancer.
- Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid–extensive binding to protein and DNA.
Black raspberry and the mouth and upper GI tract:
- New in 2015: Anti inflammatory and anti angiogenic effect of black raspberry extract on human esophageal and intestinal microvascular endothelial cells.
- New in 2015: Development and characterization of different black raspberry confection matrices designed for delivery of phytochemicals.
- Newly Added: Chemoprevention of oral cancer by topical application of black raspberries on high at-risk mucosa.
- Newly Added: Anthocyanins in black raspberries prevent esophageal tumors in rats.
- Topical application of a mucoadhesive freeze-dried black raspberry gel induces clinical and histologic regression and reduces loss of heterozygosity events in premalignant oral intraepithelial lesions: results from a multicentered, placebo-controlled clinical trial.
- Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic Acid.
- Curcumin and anthocyanin inhibit pepsin-mediated cell damage and carcinogenic changes in airway epithelial cells.
- Optimizing therapeutic efficacy of chemopreventive agents: A critical review of delivery strategies in oral cancer chemoprevention clinical trials.
- Effects of human oral mucosal tissue, saliva, and oral microflora on intraoral metabolism and bioactivation of black raspberry anthocyanins.
- Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells.
- Formulation and in vitro-in vivo evaluation of black raspberry extract-loaded PLGA/PLA injectable millicylindrical implants for sustained delivery of chemopreventive anthocyanins.
- A rapid and sensitive LC-MS/MS method for quantification of four anthocyanins and its application in a clinical pharmacology study of a bioadhesive black raspberry gel.
- Distribution of anthocyanins delivered from a bioadhesive black raspberry gel following topical intraoral application in normal healthy volunteers.
- Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions.
- Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions.
- Prevention and therapy of squamous cell carcinoma of the rodent esophagus using freeze-dried black raspberries.
- Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett’s esophagus patients.
- Suppression of the tumorigenic phenotype in human oral squamous cell carcinoma cells by an ethanol extract derived from freeze-dried black raspberries.
- Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats.
- Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS.
- Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries.
- Chemoprevention of oral cancer by black raspberries.
- Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.
- Inhibition of N-nitrosobenzylmethylamine metabolism and DNA binding in cultured rat esophagus by ellagic acid.
- Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling.
- The effect of black raspberry extracts on MnSOD activity in protection against concanavalin A induced liver injury.
- Effects of black raspberry on lipid profiles and vascular endothelial function in patients with metabolic syndrome.
- Effect of black raspberry extract in inhibiting NFkappa B dependent radioprotection in human breast cancer
- Comprehensive evaluation of caspase-14 in vulvar neoplasia: An opportunity for treatment with black raspberryextract.
- An Open-Label Randomized Crossover Trial of Lyophilized Black Raspberries on Postprandial Inflammation in Older Overweight Males: A Pilot Study.
- Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry.
- A black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells.
- Topical treatment with black raspberry extract reduces cutaneous UVB-induced carcinogenesis and inflammation.
- Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress.
- Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites.
- Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway.
- Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappaB by black raspberry extracts.
- Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants.
Black raspberry characterization:
- NMR-Based Metabolomic Investigation of Bioactivity of Chemical Constituents in Black Raspberry (Rubus occidentalis L.) Fruit Extracts.
- Nonanthocyanin Secondary Metabolites of Black Raspberry (Rubus occidentalis L.) Fruits: Identification by HPLC-DAD, NMR, HPLC-ESI-MS, and ESI-MS/MS Analyses.
- Urinary Excretion of Phenolic Acids in Rats Fed Cranberry, Blueberry, or Black Raspberry Powder.
- Modeling relationships among active components in black raspberry (Rubus occidentalis L.) fruit extracts using high-resolution (1)H nuclear magnetic resonance (NMR) spectroscopy and multivariate statistical analysis.
- Processing and storage effects on monomeric anthocyanins, percent polymeric color, and antioxidant capacity of processed black raspberry products.
- Cyanidin 3-rutinoside and cyanidin 3-xylosylrutinoside as primary phenolic antioxidants in black raspberry.
Book by Dr. Gary D. Stoner and Navindra P Seeram:
Experimental investigations in the past 10-15 years have provided convincing evidence of the cancer preventive potential of berries. Berries and their components have been shown to reduce the malignant properties of cancer cells in culture by influencing genes associated with cancer development. In addition, diets containing freeze-dried berries have been shown to prevent cancer in animals, and recent data indicate that they also exhibit cancer preventive effects in humans.
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